Fibrinogen in pregnancy

Fibrinogen in pregnancy - the norm in terms of trimesters, raising and lowering the value

As you know, pregnancy makes mandatory adjustments to the work of the woman's organism, it concerns the blood coagulation system. During pregnancy, restructuring in the body, involving blood coagulation, is necessary to maintain equilibrium in the hemostatic system, which controls the stopping of bleeding. This system is complex, it consists of two elements - a system of blood coagulation and an anticoagulant system. In order for the body to function normally, a balance is needed between these two elements of the hemostasis system. If the balance is broken for some reason, this can be fraught with serious complications during pregnancy. One of the most important components of the hemostasis system is precisely fibrinogen, the level of which is determined by special analyzes.

Since during the gestation of a baby all life-supporting systems of the body of a woman change their job, many indicators that before the pregnancy had a completely different character also changed. So, for example, if the norm of fibrinogen in the normal state is 2-4 g / l, then as the fetus develops, the protein concentration increases. The level of fibrinogen actively increases, beginning with the third trimester, and reaches a maximum value by the end of pregnancy - up to 6 g / l. This situation is associated with the emergence of a new blood circulation - utero-placental; also an increase in the values ??of the protein of blood coagulability is necessary to prevent unnecessary blood loss during the birth process.

In order to avoid possible complications caused by an imbalance in the blood clotting system, once a trimester a woman in a position needs to take the appropriate analysis - a coagulogram (or more detailed - a hemostasiogram). The analysis is carried out by taking blood from the finger, in the morning, on an empty stomach, and among other things, it allows to determine the level of fibrinogen in the blood. Deviations in indications regarding the level of fibrinogen can cause serious concern of the doctor - with such indicators the blood coagulation system is violated.

Lowering the level of fibrinogen, as a rule, is associated with severe toxicosis of the late half of pregnancy, in addition, it can be caused by DIC-syndrome, a lack of vitamins C and B12. In some cases, with a significant decrease in the indices of fibrinogen, hypofibrinogenemia may develop. The increase in the level of fibrinogen, in turn, can be caused by acute inflammatory and infectious diseases (pneumonia, influenza), tissue death.

Analysis, which allows to determine the level of fibrinogen in the blood, is a mandatory stage of prenatal diagnosis. This is another way to exclude certain possible risks for the normal development of pregnancy and subsequent childbirth.

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