Metipred is a hormonal drug based on the active substance methylprednisolone, which has anti-inflammatory, antiallergic, immunosuppressive effect. It is available in the form of tablets and powder for the preparation of injection solutions. The drug is very serious and has a number of contraindications, therefore the attending physician should carefully approach treatment, given the patient's health problems. In particular, the drug should be used with caution in case of liver failure. Among pregnancy contraindications, too. However, in some cases, and in this period, the woman is appointed by the Metipred. When does this happen?
As a rule, Metizred zaberemenevshey prescribed for threatening miscarriage. And often it has to be taken for almost the entire period. Especially if this drug helped a woman get pregnant, that is, she drank Metipred even at the stage of pregnancy planning. The drug levels the hormonal background of a future mother, when the male hormones in her body predominate (with hyperandrogenism). Although some experts believe that the appointment of Metipred (or other drugs from the group of glucocorticoids) during pregnancy can be justified only with a reliable diagnosis of PDCN (congenital adrenal cortex dysfunction).
In general, of course, the use of Metipred during pregnancy is highly undesirable. Prescribe the drug should only a doctor and only for life indications (especially in the first trimester). And it must be a doctor whom you absolutely trust. After all, the list of possible side effects of this medicine is frightening:
- from the endocrine system: a decrease in glucose tolerance, steroid diabetes, the manifestation of latent diabetes mellitus, oppression of adrenal function, Isenko- Cushing's (moonlike face, pituitary obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, striae), delayed sexual development in children;
- from the digestive system: nausea, vomiting, pancreatitis, steroid ulcer of the stomach and duodenum, erosive esophagitis, gastrointestinal bleeding, perforation of the gastrointestinal wall, impaired appetite, digestive disorders, flatulence, hiccough; rarely - increased activity of hepatic transaminases and alkaline phosphatase;
- from the cardiovascular system: arrhythmias, bradycardia (up to cardiac arrest); in predisposed patients, the development or increase in the severity of heart failure, changes in ECG, characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis; in patients with acute and subacute myocardial infarction, a foci of necrosis may spread, a delay in the formation of scar tissue, which can lead to rupture of the heart muscle;
- from the central nervous system and peripheral nervous system: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness, anxiety, insomnia, dizziness, vertigo, pseudotumor, cerebral palsy pain, cramps;
- sensory organs: posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, tendency to develop secondary bacterial, fungal or viral eye infections, trophic corneal changes, exophthalmos, sudden loss of vision (with parenteral administration head, neck, nasal concha, and scalp regions, it is possible to deposit crystals of the drug in the vessels of the eye);
- from the side of metabolism: increased excretion of calcium, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating; are caused by mineralocorticoid activity - fluid retention and sodium (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue);
- from the musculoskeletal system: slowing growth and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and femur), muscle tendon rupture , steroid myopathy, decrease in muscle mass (atrophy);
- dermatological reactions: delayed healing of wounds, petechiae, ecchymosis, thinning of the skin, hyper or hypopigmentation, steroid acne, striae, propensity to develop pyoderma and candidiasis;
- allergic reactions: skin rash, itching, anaphylactic shock, local allergic reactions. Local reactions with parenteral administration: burning, numbness, pain, tingling at the injection site, infection of the injection site; rarely - necrosis of surrounding tissues, scar formation at the injection site, atrophy of the skin and subcutaneous tissue with the / m introduction (especially dangerous is the introduction to the deltoid muscle);
- Other: development or exacerbation of infections (the appearance of this side effect is promoted by jointly used immunosuppressants and vaccination), leukocyturia, withdrawal syndrome, "hot flushes" of blood to the head.
The frequency of development and severity of side effects depends on the duration of use and the amount of dose used. Usually pregnant women are prescribed a minimum of 0. 5 tablets per day. With prolonged use of the drug, the daily dose should be reduced gradually. Long-term therapy can not be stopped suddenly.
Be careful when combining Metipred with other medicines. If you are appointed by the Metipred, check with your doctor or carefully read the instructions for exposure to other medicines. So, with paracetamol, it increases the risk of developing hepatotoxicity, and with vitamin D its effect on calcium absorption in the intestine decreases. Metipred solution is also recommended to be administered separately from other drugs.
It is considered that the use of Metipred may be especially dangerous for a future boy, since it affects the work of the adrenal glands of the fetus especially of the male sex. As a rule, children whose mothers were treated with this drug during pregnancy, after birth are fully examined, especially the kidneys and adrenal glands. And in the West, the Metipred is not used at all. But our doctors explain the purpose of this drug pregnant because it is often the only way to keep the desired pregnancy. And with small doses, Metipred is generally safe for a pregnant and unborn child, they assure. Experience shows that many women who take Metipred throughout their entire pregnancy have successfully given birth to healthy babies. But the annotations to the drug still do not inspire. If you need to apply Metipred, then find a competent specialist who will correctly choose the dosage and prescribe adequate treatment. And do not worry about anything. After all, sometimes you have to take chances to get what you want.