The norm of free T4 in women

The norm of free T4 in women

What you need to know about the thyroid hormone?

The thyroid hormone T4 (thyroxine), as well as T3 (triiodothyronine), is a hormone that is produced by the thyroid gland. More precisely, T4 is produced under the control of thyroid-stimulating hormone (TSH) follicular cells of the thyroid gland.

What does this hormone affect? T4 is one of the most important stimulators of protein synthesis, which, in addition, increases the oxygen consumption of body tissues. The latter, in turn, contributes to the improvement of nutrition and work of cells and tissues.

The amount of thyroid hormone depends on the weight of a person, because he is able to increase the rate of metabolism. It is T4 that controls the body's vitamins, and also helps the production of vitamin A in the liver. In addition, among the merits of the thyroid hormone is the decrease in the amount of cholesterol in the blood, the purification of blood vessels from so-called plaques, the fight against the formation of thrombi, the improvement of the absorption of calcium by the body, and the stimulation of the CNS (central nervous system). It is proved that thyroxine free positively influences the work of the human motor - the heart.

The hormone T4, as it turned out, is very important for the female reproductive system. In the event that its indicators deviate from the norm in the greater or lesser side, the woman may have difficulties in trying to conceive or endure the baby.

Difference between general and free thyroxine

The thyroid gland is an organ that looks like a butterfly and weighs about 15-20 grams. This gland is located from below on the front surface of the neck. Most of the hormones produced by the thyroid gland are inactive and in a bound state with the carrier protein. But there is a certain amount of free hormones. They are active and perform their functions. Total 0, 5% of T4 is represented by a free form.

As already noted in this article, T4 is associated with transport proteins, in particular, with thyroxine-binding globulin. If the number of transport proteins in the blood changes, then the level of total T4 changes, but free - there is almost no. Based on this, the level of precisely free T4 testifies to the clinical status of the thyroid status.

The norm of the hormone T4 in the body of a woman

In the blood of women, thyroxine is always less than that of men. However, during the gestation of the baby, its amount increases significantly, reaching the maximum in the last, third trimester of pregnancy. During the first forty years of life, the amount of T4 in the body is approximately the same. And both men and women. Already after 40 years, the indicators begin to change toward a decrease.

The maximum amount of this hormone is produced by the body in the morning, namely: from 8 to 12. Accordingly, the minimum - at night: from 23 to 3. Moreover, the installation / h2>

In the blood of women, thyroxine is always less than that of men. However, during the gestation of the baby, its amount increases significantly, reaching the maximum in the last, third trimester of pregnancy. During the first forty years of life, the amount of T4 in the body is approximately the same. And both men and women. Already after 40 years, the indicators begin to change toward a decrease.

The maximum amount of this hormone is produced by the body in the morning, namely: from 8 to 12. Accordingly, the minimum - at night: from 23 to 3. Moreover, the installation / h2>

In the blood of women, thyroxine is always less than that of men. However, during the gestation of the baby, its amount increases significantly, reaching the maximum in the last, third trimester of pregnancy. During the first forty years of life, the amount of T4 in the body is approximately the same. And both men and women. Already after 40 years, the indicators begin to change toward a decrease.

The maximum amount of this hormone is produced by the body in the morning, namely: from 8 to 12. Accordingly, the minimum - at night: from 23 to 3. Moreover, the installation During the first forty years of life, the amount of T4 in the body is approximately the same. And both men and women. Already after 40 years, the indicators begin to change toward a decrease.

The maximum amount of this hormone is produced by the body in the morning, namely: from 8 to 12. Accordingly, the minimum - at night: from 23 to 3. Moreover, the installation During the first forty years of life, the amount of T4 in the body is approximately the same. And both men and women. Already after 40 years, the indicators begin to change toward a decrease.

The maximum amount of this hormone is produced by the body in the morning, namely: from 8 to 12. Accordingly, the minimum - at night: from 23 to 3. Moreover, the installationthat even the seasons affect the concentration of T4 in the body. For example, in the period between September and February, the maximum concentrations of thyroid hormone are determined in the blood, and from May to September - the minimum.

If we talk about the established rate of T4 in the body of a woman, then it is from 9 to 22 picomoles per liter. Nevertheless, these indicators can vary, depending on what "malfunctions" have arisen in the work of the body. Not always deviations from the norm - this is a serious reason for unrest. But sometimes, unfortunately, significant changes in this plan can become a signal to take urgent measures, often - to medical intervention.

Reasons for raising and lowering free T4 in women

If a woman has severe illnesses, which are not associated with the thyroid gland, the concentration of free thyroxin will remain within the norm. Only occasionally in such cases it can be lowered.

A high concentration of bilirubin in the serum can contribute to the increase in the level of this hormone in the blood of a woman. Also increased T4 will be in case of obesity. And even during the procedure for taking blood from the vein, free thyroxin will be produced in more than usual quantities, due to compression caused by the imposition of a tight bundle. In addition, the causes of increased free T4 include: toxic goiter, thyrotoxic adenoma, TTG-independent thyrotoxicosis, thyroiditis, nephrotic syndrome, postpartum thyroid disorder, thyrotoxicosis, chronic liver damage. Taking certain medications also increases the level of free T4. These include aspirin, furosemide, amiodarone, tamoxifen, propylthiouracil, propranolol, levothyroxine, danazol, valproic acid.

The reasons for lowering the free thyroxin can serve as surgical operations. If a woman suffering from obesity, very much off weight, she will also be observed a decrease in this hormone. In addition, a decrease in T4 levels occurs as a result of inflammation in the pituitary or hypothalamus, Shihan syndrome, and craniocerebral trauma. In people who use heroin, taking anabolic steroids, anticonvulsants, thyreostatics, lithium preparations, octreotide, the level of free thyroxine is also lowered. Also, lowering the level of free T4 is affected by taking oral contraceptives, lack of iodine, contact with lead.

Preparing for the delivery of tests to determine the level of free T4

To submit the analysis you need to prepare well in advance. First, a month before the study should exclude the intake of any hormones, especially thyroid hormones. Secondly, a few days before taking blood for analysis should stop taking drugs that contain iodine. Thirdly, the day before blood donation completely eliminate stress and even minimal physical exertion. The ban also applies to drinking alcohol and smoking.

It's best to give blood on an empty stomach in the morning. If there is a need to donate blood not in the morning, it will be necessary to starve a little. The thing is, that between the last meal and the delivery of the test should take at least 6 hours.

Does the amount of free T4 affect the course and outcome of pregnancy?

If the indicators of free T4 are not within the limits of the norm, it can affect the nature of the course of pregnancy, both at its end and in the state of the newborn. If any thyroid disease is detected in a timely manner, if corrective actions are taken in time, then the pregnancy can both be planned and continued (in case the disease was diagnosed in a pregnant woman).

If a woman expresses endocrine pathology, the possibility of becoming pregnant sharply decreases. In most cases, this kind of pathology leads to a violation of reproductive function and infertility.

The most frequent diagnosis, associated with the thyroid gland, is the diffuse increase of this organ, better known as "goiter." But during the examination the doctor should take into account that during the period of gestation the baby changes the state of the thyroid gland. To assess the condition of this organ in pregnant women not only hormonal examination, but also ultrasound, as well as fine needle aspiration biopsy.

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